With respect to development of obesity and type-2 diabetes (T2DM), it is important to consider individual effects of different classes of nutrient or other physiological or pharmacological agents on metabolism and insulin secretion and to also acknowledge and examine the interplay between glucose metabolism and that of the two other primary nutrient classes, amino acids (such as arginine and glutamine) and free fatty acids.
It is this mixed nutrient sensing that generates the signaling for insulin release. Understanding the molecular mechanisms by which glucose, amino acids and fatty acids regulate insulin secretion form the basis to treat "diabesity".
Currently the glycemic index is commonly used to assess the glucose response, and thus insulin response, since insulin release is proportional to the glucose load. However, this may not always be the case.
Some foods may have a moderate glycemic index and higher insulin response.
Read Complete Article